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Article

Stromal Fat4 acts non-autonomously with Dachsous1/2 to restrict the nephron progenitor pool

1 Jan 2015

Abstract excerpt

Regulation of the balance between progenitor self-renewal and differentiation is crucial to development. In the mammalian kidney, reciprocal signalling between three lineages (stromal, mesenchymal and ureteric) ensures correct nephron progenitor self-renewal and differentiation. Loss of either the atypical cadherin FAT4 or its ligand Dachsous 1 (DCHS1) results in expansion of the mesenchymal nephron progenitor...

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PMID: 26116661
DOI: 10.1242/dev.122648

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