Article

<i>Hnf4a</i> is required for the development of Cdh6-expressing progenitors into proximal tubules in the mouse kidney

2020-02-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hnf4a is a major regulator of renal proximal tubule (PT) development. In humans, a mutation in HNF4A is associated with Fanconi renotubular syndrome (FRTS), which is caused by defective PT functions. In mice, mosaic deletion of Hnf4a in the developing kidney causes a paucity of PT cells, leading to FRTS-like symptoms. The molecular mechanisms underlying the role of Hnf4a i...

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Literature Corpus work: 4a0cf504-1082-5cc7-aab5-8cc7e1c3b7ff
DOI: 10.1101/2020.02.16.951731

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