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Article

Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels.

PloS one - 1 Jan 2015

He Kai, McCord Meghan C, Hartnett Karen A, Aizenman Elias

Abstract excerpt

Caspase activity during apoptosis is inhibited by physiological concentrations of intracellular K+. To enable apoptosis in injured cortical and hippocampal neurons, cellular loss of this cation is facilitated by the insertion of Kv2.1 K+ channels into the plasma membrane via a Zn2+/CaMKII/SNARE-dependent process. Pro-apoptotic membrane insertion of Kv2.1 requires the dual phosphorylation of the channel by Src and...

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Identifiers

PMID: 26115091
DOI: 10.1371/journal.pone.0129498
PMCID: PMC4482604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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