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Article

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.

The Journal of biological chemistry - 5 Apr 2013

Hossain M Iqbal, Roulston Carli L, Kamaruddin M Aizuddin, Chu Percy W Y, Ng Dominic C H, Dusting Gregory J, Bjorge Jeffrey D, Williamson Nicholas A, Fujita Donald J, Cheung Steve N, Chan Tung O, Hill Andrew F, Cheng Heung-Chin

Abstract excerpt

Excitotoxicity resulting from overstimulation of glutamate receptors is a major cause of neuronal death in cerebral ischemic stroke. The overstimulated ionotropic glutamate receptors exert their neurotoxic effects in part by overactivation of calpains, which induce neuronal death by catalyzing li...

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Identifiers

PMID: 23400779
DOI: 10.1074/jbc.M112.419713
PMCID: PMC3617272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23400779-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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