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Article

Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2012

Norris Callie A, He Kai, Springer Mitchell G, Hartnett Karen A, Horn John P, Aizenman Elias

Abstract excerpt

Apoptosis-enabling neuronal potassium efflux is mediated by an enhancement of K+ currents. In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800. It was recently shown that a K+ current surge is also present in hepa...

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Identifiers

PMID: 22745487
DOI: 10.1523/JNEUROSCI.0937-12.2012
PMCID: PMC3388847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22745487-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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