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Article

ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit.

American journal of physiology. Cell physiology - 1 Mar 2006

Schrader Laura A, Birnbaum Shari G, Nadin Brian M, Ren Yajun, Bui Duy, Anderson Anne E, Sweatt J David

Abstract excerpt

Kv4.2 is the primary pore-forming subunit encoding A-type currents in many neurons throughout the nervous system, and it also contributes to the transient outward currents of cardiac myocytes. A-type currents in the dendrites of hippocampal CA1 pyramidal neurons are regulated by activation of ERK/MAPK, and Kv4.2 is the likely pore-forming subunit of that current. We showed previously that Kv4.2 is directly...

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Identifiers

PMID: 16251476
DOI: 10.1152/ajpcell.00358.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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