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Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications

10 Jun 2015

Abstract excerpt

Given their rapid and efficient capacity to recognize and kill tumor cells, natural killer (NK) cells represent a unique immune cell to genetically reprogram in an effort to improve the outcome of cell-based cancer immunotherapy. However, technical and biological challenges associated with gene delivery into NK cells have significantly tempered this approach. Recent advances in viral transduction and...

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PMID: 26113846
DOI: 10.3389/fimmu.2015.00266

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