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Genetic Manipulation Approaches to Enhance the Clinical Application of NK Cell-Based Immunotherapy

24 Dec 2023

Abstract excerpt

Natural killer (NK) cells are a subset of cytotoxic lymphocytes within the innate immune system. While they are naturally cytotoxic, genetic modifications can enhance their tumor-targeting capability, cytotoxicity, persistence, tumor infiltration, and prevent exhaustion. These improvements hold the potential to make NK-cell-based immunotherapies more effective in clinical applications. Currently, several viral...

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PMID: 38142460
DOI: 10.1093/stcltm/szad087

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