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Application and prospects of genetic engineering in CAR-NK cell therapy

23 May 2025

Abstract excerpt

With the rapid advancement of genetic engineering technologies, CAR-NK cell therapy, as an emerging immunotherapeutic approach, has demonstrated significant potential. CAR-NK cells recognize and eliminate tumor cells through chimeric antigen receptors (CARs). Genetic engineering techniques have enhanced the targeting and anti-tumor activity of CAR-NK cells by optimizing key components of the CAR structure, such...

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PMID: 40486523
DOI: 10.3389/fimmu.2025.1600411

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