Article
Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein.
Science (New York, N.Y.) - 17 Jul 2015
Winzer Thilo, Kern Marcelo, King Andrew J, Larson Tony R, Teodor Roxana I, Donninger Samantha L, Li Yi, Dowle Adam A, Cartwright Jared, Bates Rachel, Ashford David, Thomas Jerry, Walker Carol, Bowser Tim A, Graham Ian A
Abstract excerpt
Morphinan alkaloids from the opium poppy are used for pain relief. The direction of metabolites to morphinan biosynthesis requires isomerization of (S)- to (R)-reticuline. Characterization of high-reticuline poppy mutants revealed a genetic locus, designated STORR [(S)- to (R)-reticuline] that encodes both cytochrome P450 and oxidoreductase modules, the latter belonging to the aldo-keto reductase family....
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