Article
Analgesia: morphine-pathway block in top1 poppies.
Nature - 23 Sept 2004
Millgate Anthony G, Pogson Barry J, Wilson Iain W, Kutchan Toni M, Zenk Meinhart H, Gerlach Wayne L, Fist Anthony J, Larkin Philip J
Abstract excerpt
The opium poppy is a source of the pharmaceuticals codeine, morphine and their derived analgesics. Here we describe the initial characterization of the poppy mutant known as top1 (for 'thebaine oripavine poppy 1'), which accumulates the morphine and codeine precursors thebaine and oripavine and does not complete their biosynthesis into morphine and codeine. The original discovery of top1 stimulated a...
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