Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum.

doi:10.1046/j.1365-313x.1999.00470.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum.

The Plant journal : for cell and molecular biology - 1 Jun 1999

Unterlinner B, Lenz R, Kutchan T M

Abstract excerpt

The narcotic analgesic morphine is the major alkaloid of the opium poppy Papaver somniferum. Its biosynthetic precursor codeine is currently the most widely used and effective antitussive agent. Along the morphine biosynthetic pathway in opium poppy, codeinone reductase catalyzes the NADPH-depend...

Topics

Alcohol Oxidoreductases
Alleles
Amino Acid Sequence
Cloning, Molecular
DNA, Complementary
Genes, Plant
Isoenzymes
Models, Chemical
Molecular Sequence Data
Morphine
NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papaver

Plants, Medicinal

Polymerase Chain Reaction

RNA, Messenger

RNA, Plant

Sequence Homology, Amino Acid

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 10417697
DOI: 10.1046/j.1365-313x.1999.00470.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10417697-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum.PMID 10417697Read ↗

Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesisSemantic proximity Read ↗

Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein.Semantic proximity Read ↗

Redesign of a dioxygenase in morphine biosynthesis.Semantic proximity Read ↗

Uncovering the molecular basis of high morphinan product efficiency in opium poppy through Multi-omics integrated analysis with multi-capsules.Semantic proximity Read ↗

Comparative analysis of Papaver somniferum genotypes having contrasting latex and alkaloid profiles.Semantic proximity Read ↗

A <i>Papaver somniferum</i> 10-Gene Cluster for Synthesis of the Anticancer Alkaloid NoscapineSemantic proximity Read ↗

Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis.Semantic proximity Read ↗

Developing benzylisoquinoline alkaloid-enriched opium poppy via CRISPR-directed genome editing: A reviewSemantic proximity Read ↗

Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum).Semantic proximity Read ↗

Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis.Semantic proximity Read ↗

Cloning and Characterization of a Norbelladine 4′-O-Methyltransferase Involved in the Biosynthesis of the Alzheimer’s Drug Galanthamine in Narcissus sp. aff. pseudonarcissusSemantic proximity Read ↗

Analgesia: morphine-pathway block in top1 poppies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.