Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Redesign of a dioxygenase in morphine biosynthesis.

Chemistry & biology - 22 Jun 2012

Runguphan Weerawat, Glenn Weslee S, O'Connor Sarah E

Abstract excerpt

Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, including the analgesics codeine and morphine, in the morphinan pathway. We aligned three dioxygenases that were recently discovered in P. somniferum and subsequently identified the nonconserved regions. Two of these enzymes, codeine O-demethylase (PsCODM) and thebaine O-demethylase (PsT6ODM), are known to facilitate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Engineering
Share to Kinetics
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Structure

Share to Morphine

Share to Mutation

Share to Dioxygenases

Source

Identifiers

PMID: 22726681
DOI: 10.1016/j.chembiol.2012.04.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Redesign of a dioxygenase in morphine biosynthesis.PMID 22726681Read ↗

Developing benzylisoquinoline alkaloid-enriched opium poppy via CRISPR-directed genome editing: A reviewSemantic proximity Read ↗

Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesisSemantic proximity Read ↗

Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum.Semantic proximity Read ↗

Analgesia: morphine-pathway block in top1 poppies.Semantic proximity Read ↗

Uncovering the molecular basis of high morphinan product efficiency in opium poppy through Multi-omics integrated analysis with multi-capsules.Semantic proximity Read ↗

Piperazine ring formation by a single-module NRPS and cleavage by an α-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis.Semantic proximity Read ↗

Construction of a high-efficiency GjCCD4a mutant and its application for de novo biosynthesis of five crocins in Escherichia coli.Semantic proximity Read ↗

Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein.Semantic proximity Read ↗

Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis.Semantic proximity Read ↗

Designing an Artificial Pathway for the Biosynthesis of a Novel Phenazine N-Oxide in Pseudomonas chlororaphis HT66Semantic proximity Read ↗

Examination and expansion of the substrate range of m-hydroxybenzoate hydroxylase.Semantic proximity Read ↗

Artificial dicopper oxidase: rational reprogramming of bacterial metallo-β-lactamase into a catechol oxidase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.