Article
Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis.
PloS one - 1 Jan 2013
Pathak Sumya, Lakhwani Deepika, Gupta Parul, Mishra Brij Kishore, Shukla Sudhir, Asif Mehar Hasan, Trivedi Prabodh Kumar
Abstract excerpt
The benzylisoquinoline alkaloid papaverine, synthesized in low amount in most of the opium poppy varieties of Papaver somniferum, is used as a vasodilator muscle relaxant and antispasmodic. Papaverine biosynthesis remains controversial as two different routes utilizing either (S)-coclaurine or (S)-reticuline have been proposed with uncharacterized intermediate steps. In an attempt to elucidate papaverine...
Topics
- Gene Expression Profiling
- Genomics
- High-Throughput Nucleotide Sequencing
- Methyltransferases
- Molecular Sequence Annotation
- Mutation
- Oxidoreductases
- Pancreatitis-Associated Proteins
- Papaver
- Papaverine