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Article

A <i>Papaver somniferum</i> 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

1 Jun 2012

Abstract excerpt

Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase, and induces apoptosis in dividing human cells. Elucidation of the biosynthetic pathway will enable improvement in the commercial production of noscapine and related bioactive molecules. Transcriptomic analysis revealed the exclusive expression of 10 genes encoding five distinct enzyme classes in a high noscapine-producing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22653730
DOI: 10.1126/science.1220757

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