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Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum).

The Journal of biological chemistry - 25 Feb 2011

Higashi Yasuhiro, Kutchan Toni M, Smith Thomas J

Abstract excerpt

The opium poppy (Papaver somniferum L.) is one of the oldest known medicinal plants. In the biosynthetic pathway for morphine and codeine, salutaridine is reduced to salutaridinol by salutaridine reductase (SalR; EC 1.1.1.248) using NADPH as coenzyme. Here, we report the atomic structure of SalR to a resolution of ∼1.9 Å in the presence of NADPH. The core structure is highly homologous to other members of the...

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Catalysis
Crystallography, X-Ray
Models, Molecular
Mutation
NADP
Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

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PMID: 21169353
DOI: 10.1074/jbc.M110.168633
PMCID: PMC3057844

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