Article
Plant P450s as versatile drivers for evolution of species-specific chemical diversity.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Feb 2013
Hamberger Björn, Bak Søren
Abstract excerpt
The irreversible nature of reactions catalysed by P450s makes these enzymes landmarks in the evolution of plant metabolic pathways. Founding members of P450 families are often associated with general (i.e. primary) metabolic pathways, restricted to single copy or very few representatives, indicative of purifying selection. Recruitment of those and subsequent blooms into multi-member gene families generates...
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