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CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesity

19 Sept 2024

Abstract excerpt

OBJECTIVE: Brown adipose tissue (BAT) plays an important role in mammalian thermogenesis through the expression of uncoupling protein 1 (UCP1). Our previous study identified cytoplasmic polyadenylation element binding protein 2 (CPEB2) as a key regulator that activates the translation of Ucp1 with a long 3'-untranslated region (Ucp1L) in response to adrenergic signaling. Mice lacking CPEB2 or Ucp1L exhibited...

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PMID: 39305947
DOI: 10.1016/j.molmet.2024.102034

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