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Article

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.

Genes & development - 1 Jan 2010

Wethmar Klaus, Bégay Valérie, Smink Jeske J, Zaragoza Katrin, Wiesenthal Volker, Dörken Bernd, Calkhoven Cornelis F, Leutz Achim

Abstract excerpt

Upstream ORFs (uORFs) are translational control elements found predominantly in transcripts of key regulatory genes. No mammalian genetic model exists to experimentally validate the physiological relevance of uORF-regulated translation initiation. We report that mice deficient for the CCAAT/enhancer-binding protein beta (C/EBPbeta) uORF initiation codon fail to initiate translation of the autoantagonistic LIP...

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Identifiers

PMID: 20047998
DOI: 10.1101/gad.557910
PMCID: PMC2802187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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