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Article

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.

Scientific reports - 30 May 2018

Bégay Valérie, Baumeier Christian, Zimmermann Karin, Heuser Arnd, Leutz Achim

Abstract excerpt

The transcription factor C/EBPβ regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPβ protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start sites to generate three isoforms, two long (LAP*, LAP) and one truncated (LIP), with the same C-terminal bZip dimerization domain. The long C/EBPβ isoforms are...

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Identifiers

PMID: 29849099
DOI: 10.1038/s41598-018-26579-y
PMCID: PMC5976626

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