Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle.

The Journal of biological chemistry - 20 Jul 2007

Southgate Robert J, Neill Bronwyn, Prelovsek Oja, El-Osta Assam, Kamei Yasutomi, Miura Shinji, Ezaki Osamu, McLoughlin Thomas J, Zhang Wenwei, Unterman Terry G, Febbraio Mark A

Abstract excerpt

The mammalian target of rapamycin (mTOR) is regulated by growth factors to promote protein synthesis. In mammalian skeletal muscle, the Forkhead-O1 transcription factor (FOXO1) promotes catabolism by activating ubiquitin-protein ligases. Using C2C12 mouse myoblasts that stably express inducible F...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Eukaryotic Initiation Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Muscle, Skeletal

Share to Phosphoproteins

Share to Protein Kinases

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 17510058
DOI: 10.1074/jbc.M702039200

Genes

FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17510058-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle.PMID 17510058Read ↗

The multifaceted impact of physical exercise on FoxO signaling pathwaysSemantic proximity Read ↗

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle AtrophySemantic proximity Read ↗

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin LigasesSemantic proximity Read ↗

The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.Semantic proximity Read ↗

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid MetabolismSemantic proximity Read ↗

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophySemantic proximity Read ↗

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.Semantic proximity Read ↗

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factorSemantic proximity Read ↗

FoxO3 Controls Autophagy in Skeletal Muscle In VivoSemantic proximity Read ↗

Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors.Semantic proximity Read ↗

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexiaSemantic proximity Read ↗

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.