Article
The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.
PloS one - 1 Feb 2010
Csibi Alfredo, Cornille Karen, Leibovitch Marie-Pierre, Poupon Anne, Tintignac Lionel A, Sanchez Anthony M J, Leibovitch Serge A
Abstract excerpt
The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E-BP1. mTOR and S6K1 are connected by interacting with the eIF3 initiation complex. The regulatory subunit eIF3f plays a major role in muscle hypertrophy and is a key target that accounts for MAFbx function during atrophy. Here we present...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.