Article
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.
The Journal of pathology - 1 Apr 2012
Aichler Michaela, Seiler Christopher, Tost Monica, Siveke Jens, Mazur Pawel K, Da Silva-Buttkus Patricia, Bartsch Detlef K, Langer Peter, Chiblak Sara, Dürr Anna, Höfler Heinz, Klöppel Günter, Müller-Decker Karin, Brielmeier Markus, Esposito Irene
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions, pancreatic intraepithelial neoplasia (PanIN), display a ductal phenotype. However, there is evidence in genetically defined mouse models for PDAC harbouring a mutated kras under the control of a pancreas-specific promoter that ductal cancer might arise in the centroacinar-acinar region, possibly through a process of acinar-ductal metaplasia (ADM)....
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