Article
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.
Cancer research - 15 Aug 2015
Rajeshkumar N V, Dutta Prasanta, Yabuuchi Shinichi, de Wilde Roeland F, Martinez Gary V, Le Anne, Kamphorst Jurre J, Rabinowitz Joshua D, Jain Sanjay K, Hidalgo Manuel, Dang Chi V, Gillies Robert J, Maitra Anirban
Abstract excerpt
The "Warburg effect" describes a peculiar metabolic feature of many solid tumors, namely their increased glucose uptake and high glycolytic rates, which allow cancer cells to accumulate building blocks for the biosynthesis of macromolecules. During aerobic glycolysis, pyruvate is preferentially metabolized to lactate by the enzyme lactate dehydrogenase-A (LDH-A), suggesting a possible vulnerability at this target...
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