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Article

p53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect.

Bulletin of mathematical biology - 29 Aug 2024

Abukwaik Roba, Vera-Siguenza Elias, Tennant Daniel, Spill Fabian

Abstract excerpt

Cancer cells exhibit significant alterations in their metabolism, characterised by a reduction in oxidative phosphorylation (OXPHOS) and an increased reliance on glycolysis, even in the presence of oxygen. This metabolic shift, known as the Warburg effect, is pivotal in fuelling cancer's uncontrolled growth, invasion, and therapeutic resistance. While dysregulation of many genes contributes to this metabolic...

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Identifiers

PMID: 39207627
DOI: 10.1007/s11538-024-01346-5
PMCID: PMC11362376

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