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Article

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas.

Oncotarget - 3 Jan 2017

Li Yaqing, Li Xiaoran, Kan Quancheng, Zhang Mingzhi, Li Xiaoli, Xu Ruiping, Wang Junsheng, Yu Dandan, Goscinski Mariusz Adam, Wen Jian-Guo, Nesland Jahn M, Suo Zhenhe

Abstract excerpt

Aerobic glycolysis is one of the emerging hallmarks of cancer cells. In this study, we investigated the relationship between blocking mitochondrial pyruvate carrier (MPC) with MPC blocker UK5099 and the metabolic alteration as well as aggressive features of esophageal squamous carcinoma. It was found that blocking pyruvate transportation into mitochondria attenuated mitochondrial oxidative phosphorylation...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Squamous Cell Carcinoma

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Share to Mitochondrial Membrane Transport Proteins

Share to Monocarboxylic Acid Transporters

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Source

Open in PubMed Open full text

Identifiers

PMID: 27911865
DOI: 10.18632/oncotarget.13717
PMCID: PMC5352034

Genes

MPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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