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A positive feedback between HIF1α and lysyl oxidase-like 2 dictates the Warburg Effect in Pancreatic Cancer

2021-04-06

Abstract excerpt

<h4>Background: </h4> Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely unknown. Methods The expression pattern and prognostic value of LOXL2 was analyzed by immunohistochemistry. The effects of LOXL2 on cancer...

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Literature Corpus work
c6aa6902-999c-59ad-97e7-a6fa6c3a0e62
DOI
10.21203/rs.3.rs-360740/v1
Open publication

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A positive feedback between HIF1α and lysyl oxidase-like 2 dictates the Warburg Effect in Pancreatic CancerDOI 10.21203/rs.3.rs-360740/v1
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