Article
The association between GGCX, miR-133 genetic polymorphisms and warfarin stable dosage in Han Chinese patients with mechanical heart valve replacement.
Journal of clinical pharmacy and therapeutics - 1 Aug 2017
Tang X-Y, Zhang J, Peng J, Tan S-L, Zhang W, Song G-B, Liu L-M, Li C-L, Ren H, Zeng L, Liu Z-Q, Chen X-P, Zhou X-M, Zhou H-H, Hu J-X, Li Z
Abstract excerpt
WHAT IS KNOWN AND OBJECTIVE: Warfarin is a widely used anticoagulant with a narrow therapeutic index. Polymorphisms in the VKORC1, CYP2C9 and CYP4F2 genes have been verified to correlate with warfarin stable dosage (WSD). Whether any other genes or variants affect the dosage is unknown. The aim of our study was to investigate the relationship between GGCX, miR-133 variants and the WSD in Han Chinese patients with...
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