Article
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.
Blood - 6 May 2010
Limdi Nita A, Wadelius Mia, Cavallari Larisa, Eriksson Niclas, Crawford Dana C, Lee Ming-Ta M, Chen Chien-Hsiun, Motsinger-Reif Alison, Sagreiya Hersh, Liu Nianjun, Wu Alan H B, Gage Brian F, Jorgensen Andrea, Pirmohamed Munir, Shin Jae-Gook, Suarez-Kurtz Guilherme, Kimmel Stephen E, Johnson Julie A, Klein Teri E, Wagner Michael J
Abstract excerpt
Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 -1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic factors. However, these algorithms better capture dose variability among whites than Asians or blacks. Herein, we evaluate whether other VK...
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