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Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer.

Anti-cancer drugs - 1 Sept 2015

Wu Nai-Chun, Su Shih-Ming, Lin Tai-Jung, Chin Jen, Hou Chun-Fang, Yang Jhong-Ying, Liu Wen-Sheng, Chang Li-Ching

Abstract excerpt

This study aimed to investigate the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and the prognosis of colorectal cancer (CRC) patients undergoing 5-fluorouracil (5-FU)-based chemotherapy in Taiwan. We investigated 126 CRC cases. The most common polymorphisms C677T (rs1801133) and A1298C (rs1801131) in MTHFR were genotyped using PCR-restriction fragment length polymorphism....

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Source

Identifiers

PMID: 26111049
DOI: 10.1097/CAD.0000000000000261

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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