Article
Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review.
American journal of epidemiology - 15 Nov 2009
Taioli E, Garza M A, Ahn Y O, Bishop D T, Bost J, Budai B, Chen K, Gemignani F, Keku T, Lima C S P, Le Marchand L, Matsuo K, Moreno V, Plaschke J, Pufulete M, Thomas S B, Toffoli G, Wolf C R, Moore C G, Little J
Abstract excerpt
Worldwide, over 1 million cases of colorectal cancer (CRC) were reported in 2002, with a 50% mortality rate, making CRC the second most common cancer in adults. Certain racial/ethnic populations continue to experience a disproportionate burden of CRC. A common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been associated with a lower risk of CRC. The authors performed both a...
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