Article
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population.
Genetics and molecular research : GMR - 14 Dec 2011
Li H, Xu W L, Shen H L, Chen Q Y, Hui L L, Long L L, Zhu X L
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a cas...
Topics
- Aged
- Asian People
- China
- Colorectal Neoplasms
- Ethnicity
- Female
- Folic Acid
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genetics, Population
- Haplotypes
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Odds Ratio
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length