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Article

Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.

International journal of clinical oncology - 1 Jun 2017

Yeh Chih-Ching, Lai Ching-Yu, Chang Shih-Ni, Hsieh Ling-Ling, Tang Reiping, Sung Fung-Chang, Lin Yi-Kuei

Abstract excerpt

BACKGROUND: This study examined the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and survival of patients with colorectal cancer (CRC) treated with 5-fluorouracil (5-FU)-based chemotherapy in Taiwan. METHODS: We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery. Survival analyses...

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PMID: 28044213
DOI: 10.1007/s10147-016-1080-z

Genes

MTHFR

Variants

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Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.PMID 28044213Read ↗

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