Article
The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies.
PloS one - 1 Jan 2013
Teng Zan, Wang Lei, Cai Shuang, Yu Ping, Wang Jin, Gong Jing, Liu Yunpeng
Abstract excerpt
BACKGROUND: The 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene is considered to have a significant effect on colorectal cancer susceptibility, but the results are inconsistent. In order to investigate the association between the MTHFR 677C>T polymorphism and the risk of colorectal cancer, a meta-analysis was held based on 71 published studies. METHODS: Eligible studies were identified...
Topics
- Colorectal Neoplasms
- Confidence Intervals
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Single Nucleotide
- Publication Bias
- Risk Factors