Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.

Molecular biology reports - 1 Oct 2012

Sheng Xuewen, Zhang Yanxi, Zhao Erjiang, Lu Su, Zheng Xiaoli, Ge Hong, Lu Weiquan

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is believed to be involved in folate metabolism which plays a critical role in carcinogenesis. To date, many case-control studies have investigated the association between MTHFR C677T polymorphism and colorectal cancer risk. However, the results were inconsistent. In order to derive a more precise estimation of the association, we conducted this meta-analysis. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Publication Bias

Share to Sex Factors

Source

Identifiers

PMID: 22729883
DOI: 10.1007/s11033-012-1832-4

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.PMID 22729883Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies.Semantic proximity Read ↗

Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations.Semantic proximity Read ↗

The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.Semantic proximity Read ↗

MTHFR C677T polymorphism and colorectal cancer risk in Asians, a meta-analysis of 21 studies.Semantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase polymorphisms and colon cancer risk: a meta-analysis.Semantic proximity Read ↗

Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.Semantic proximity Read ↗

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.Semantic proximity Read ↗

Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer.Semantic proximity Read ↗

MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations.Semantic proximity Read ↗

Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.