Article
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2009
Afzal S, Jensen S A, Vainer B, Vogel U, Matsen J P, Sørensen J B, Andersen P K, Poulsen H E
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical efficacy, but further studies have yielded contradictory results. We tested whether these two polymorphisms...
Topics
- Antimetabolites, Antineoplastic
- Chemotherapy, Adjuvant
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Denmark
- Disease-Free Survival
- Female