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Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome

24 Jun 2015

Abstract excerpt

BACKGROUND: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers. The aim of this study was to determine whether use of aspirin and...

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PMID: 26109217
DOI: 10.1093/jnci/djv170

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