Article
Associations Between Mutations in MSH6 and PMS2 and Risk of Surveillance-detected Colorectal Cancer.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Nov 2020
Lamba Mehul, Wakeman Chris, Ebel Rosy, Hamilton Sarah, Frampton Chris, Kiesanowski Maxene, Griffiths Ben, Keating John, Parry Susan, Chalmers-Watson Teresa
Abstract excerpt
BACKGROUND & AIMS: Lynch syndrome is the most common inherited cause of colorectal cancer (CRC). Contemporary and mutation-specific estimates of CRC-risk in patients undergoing colonoscopy would optimize surveillance strategies. We performed a prospective national cohort study, using data from New Zealand, to assess overall and mutation-specific risk of CRC in patients with Lynch syndrome undergoing surveillance....
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