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Article

Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer.

The New England journal of medicine - 29 Jun 2006

Barnetson Rebecca A, Tenesa Albert, Farrington Susan M, Nicholl Iain D, Cetnarskyj Roseanne, Porteous Mary E, Campbell Harry, Dunlop Malcolm G

Abstract excerpt

BACKGROUND: The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease. METHODS: Without preselection and regardless of family history, we recruited 870 patients under the age of 55 years soon after they received a diagnosis of colorectal cancer. We studied these patients for germ-line mutations in the DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16807412
DOI: 10.1056/NEJMoa053493

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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