Article
Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers.
Annals of surgical oncology - 1 Jun 2013
Win Aung Ko, Parry Susan, Parry Bryan, Kalady Matthew F, Macrae Finlay A, Ahnen Dennis J, Young Graeme P, Lipton Lara, Winship Ingrid, Boussioutas Alex, Young Joanne P, Buchanan Daniel D, Arnold Julie, Le Marchand Loïc, Newcomb Polly A, Haile Robert W, Lindor Noralane M, Gallinger Steven, Hopper John L, Jenkins Mark A
Abstract excerpt
BACKGROUND: Despite regular surveillance colonoscopy, the metachronous colorectal cancer risk for mismatch repair (MMR) gene mutation carriers after segmental resection for colon cancer is high and total or subtotal colectomy is the preferred option. However, if the index cancer is in the rectum, management decisions are complicated by considerations of impaired bowel function. We aimed to estimate the risk of...
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