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Article

Aspirin use and risk of colorectal cancer according to BRAF mutation status.

JAMA - 26 Jun 2013

Nishihara Reiko, Lochhead Paul, Kuchiba Aya, Jung Seungyoun, Yamauchi Mai, Liao Xiaoyun, Imamura Yu, Qian Zhi Rong, Morikawa Teppei, Wang Molin, Spiegelman Donna, Cho Eunyoung, Giovannucci Edward, Fuchs Charles S, Chan Andrew T, Ogino Shuji

Abstract excerpt

IMPORTANCE: Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), suggesting that BRAF-mutant colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type neoplastic cells. OBJECTIVE: To examine whether the association of aspirin intake with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23800934
DOI: 10.1001/jama.2013.6599
PMCID: PMC3743040

Genes

BRAF
PTGS2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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