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Article

Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome.

Gastroenterology - 1 Aug 2021

Kastrinos Fay, Ingram Myles A, Silver Elisabeth R, Oh Aaron, Laszkowska Monika, Rustgi Anil K, Hur Chin

Abstract excerpt

BACKGROUND AND AIMS: Lynch syndrome is associated with pathogenic variants in 4 mismatch repair (MMR) genes that increase lifetime risk of colorectal cancer. Guidelines recommend intensive colorectal cancer surveillance with colonoscopy every 1-2 years starting at age 25 years for all carriers of Lynch syndrome-associated variants, regardless of gene product. We constructed a simulation model to analyze the...

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Identifiers

PMID: 33839100
DOI: 10.1053/j.gastro.2021.04.010
PMCID: PMC9330543

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