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Article

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP.

Genes & development - 15 Jun 2015

Chen Qian, Zhang Nailing, Xie Rui, Wang Wei, Cai Jing, Choi Kyung-Suk, David Karen Kate, Huang Bo, Yabuta Norikazu, Nojima Hiroshi, Anders Robert A, Pan Duojia

Abstract excerpt

The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose phosphorylation is believed to inhibit YAP by excluding it from the nucleus. Indeed, nuclear localization of YAP or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26109051
DOI: 10.1101/gad.264234.115
PMCID: PMC4495399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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