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Article

cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.

The EMBO journal - 29 May 2013

Kim Minchul, Kim Miju, Lee Seunghee, Kuninaka Shinji, Saya Hideyuki, Lee Ho, Lee Sookyung, Lim Dae-Sik

Abstract excerpt

Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes-associated protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) inactivates YAP by phosphorylating its Ser127 and Ser381 residues. However, the events downstream of actin cytoskeletal changes that are involved in the regulation of the LATS-YAP pathway and the mechanism by which LATS differentially...

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Identifiers

PMID: 23644383
DOI: 10.1038/emboj.2013.102
PMCID: PMC3671250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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