Article
The roles of YAP T425A mutation in the regulation of YAP activity.
Yi chuan = Hereditas - 20 Jul 2017
Yang Yang-lu, Zou Zhuang-zhi, Fang Yuan, Mao Beibei
Abstract excerpt
The Hippo signaling pathway plays a critical role in body development and tissue growth. As the core effector of the Hippo signaling pathway, Yes-associated protein (YAP) has been reported to be involved in various kinds of human cancers. However, the mechanism for the regulation of YAP activity has not been completely understood. In this study, we constructed a YAP Thr425Ala mutant and found that this mutation...
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