Article
Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.
Chromosoma - 1 Mar 2014
Ontoso David, Kauppi Liisa, Keeney Scott, San-Segundo Pedro A
Abstract excerpt
During meiotic prophase I, interactions between maternal and paternal chromosomes, under checkpoint surveillance, establish connections between homologs that promote their accurate distribution to meiotic progeny. In human, faulty meiosis causes aneuploidy resulting in miscarriages and genetic diseases. Meiotic processes occur in the context of chromatin; therefore, histone post-translational modifications are...
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