Article
Procoagulant phenotype induced by oxidized high-density lipoprotein associates with acute kidney injury and death.
Thrombosis research - 1 Mar 2023
Prado Yolanda, Pérez Lorena, Eltit Felipe, Echeverría Cesar, Llancalahuen Felipe M, Tapia Pablo, González Pablo A, Kalergis Alexis M, Cabello-Verrugio Claudio, Simon Felipe
Abstract excerpt
BACKGROUND: Oxidative stress derived from severe systemic inflammation promotes conversion from high-density lipoprotein HDL to oxidized HDL (oxHDL), which interacts with vascular endothelial cells (ECs). OxHDL acquires procoagulant features playing a role in modulating coagulation, which has been linked with organ failure in ICU patients. However, whether oxHDL elicits a ECs-mediated procoagulant phenotype...
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