Article
A genome-wide association study identifies multiple loci for variation in human ear morphology.
Nature communications - 24 Jun 2015
Adhikari Kaustubh, Reales Guillermo, Smith Andrew J P, Konka Esra, Palmen Jutta, Quinto-Sanchez Mirsha, Acuña-Alonzo Victor, Jaramillo Claudia, Arias William, Fuentes Macarena, Pizarro María, Barquera Lozano Rodrigo, Macín Pérez Gastón, Gómez-Valdés Jorge, Villamil-Ramírez Hugo, Hunemeier Tábita, Ramallo Virginia, Silva de Cerqueira Caio C, Hurtado Malena, Villegas Valeria, Granja Vanessa, Gallo Carla, Poletti Giovanni, Schuler-Faccini Lavinia, Salzano Francisco M, Bortolini Maria-Cátira, Canizales-Quinteros Samuel, Rothhammer Francisco, Bedoya Gabriel, Calderón Rosario, Rosique Javier, Cheeseman Michael, Bhutta Mahmood F, Humphries Steve E, Gonzalez-José Rolando, Headon Denis, Balding David, Ruiz-Linares Andrés
Abstract excerpt
Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find genome-wide significant association at seven genomic regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion and antitragus size (linear regression P values 2 × 10(-8) to 3 × 10(-14)). Four traits are associated with a functional variant in the...
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