Article
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation.
Nature communications - 19 May 2016
Adhikari Kaustubh, Fuentes-Guajardo Macarena, Quinto-Sánchez Mirsha, Mendoza-Revilla Javier, Camilo Chacón-Duque Juan, Acuña-Alonzo Victor, Jaramillo Claudia, Arias William, Lozano Rodrigo Barquera, Pérez Gastón Macín, Gómez-Valdés Jorge, Villamil-Ramírez Hugo, Hunemeier Tábita, Ramallo Virginia, Silva de Cerqueira Caio C, Hurtado Malena, Villegas Valeria, Granja Vanessa, Gallo Carla, Poletti Giovanni, Schuler-Faccini Lavinia, Salzano Francisco M, Bortolini Maria-Cátira, Canizales-Quinteros Samuel, Cheeseman Michael, Rosique Javier, Bedoya Gabriel, Rothhammer Francisco, Headon Denis, González-José Rolando, Balding David, Ruiz-Linares Andrés
Abstract excerpt
We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10(-8)) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of ∼3,000...
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