Article
Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci.
PLoS genetics - 1 Jul 2023
Li Yi, Xiong Ziyi, Zhang Manfei, Hysi Pirro G, Qian Yu, Adhikari Kaustubh, Weng Jun, Wu Sijie, Du Siyuan, Gonzalez-Jose Rolando, Schuler-Faccini Lavinia, Bortolini Maria-Catira, Acuna-Alonzo Victor, Canizales-Quinteros Samuel, Gallo Carla, Poletti Giovanni, Bedoya Gabriel, Rothhammer Francisco, Wang Jiucun, Tan Jingze, Yuan Ziyu, Jin Li, Uitterlinden André G, Ghanbari Mohsen, Ikram M Arfan, Nijsten Tamar, Zhu Xiangyu, Lei Zhen, Jia Peilin, Ruiz-Linares Andres, Spector Timothy D, Wang Sijia, Kayser Manfred, Liu Fan
Abstract excerpt
Human ear morphology, a complex anatomical structure represented by a multidimensional set of correlated and heritable phenotypes, has a poorly understood genetic architecture. In this study, we quantitatively assessed 136 ear morphology traits using deep learning analysis of digital face images in 14,921 individuals from five different cohorts in Europe, Asia, and Latin America. Through GWAS meta-analysis and...
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